wnt4 proto-oncogene protein

Function

• required for Mullerian duct formation
• in the developing ovary, appears to suppress development of Leydig cells
• ligand for members of the frizzled family
• probable developmental protein
• may be a signaling molecule which affects the development of discrete regions of tissues
• likely to signal over only few cell diameters (putative)
• overexpression may be associated with abnormal proliferation in human breast tissue
• interacts with PORCN (putative)

Structure

belongs to the Wnt family

Compartment

• secreted, extracellular space, extracellular matrix

Pathology

• defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome

More general terms

• wnt proto-oncogene protein or int proto-oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5436
• OMIM: https://mirror.omim.org/entry/277000
• OMIM: https://mirror.omim.org/entry/603490
• UniProt: http://www.uniprot.org/uniprot/P56705.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54361