wnt7A proto-oncogene protein

Function

• ligand for members of the frizzled family
• probable developmental protein
• signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (putative)
• interacts with PORCN (putative)
• when secreted by cerebellar granule cells, induces axonal remodeling & synaptic differentiation in mossy fibers
• regulates synapsin 1 accumulation

Structure

belongs to the Wnt family

Compartment

• secreted, extracellular space, extracellular matrix

Expression

• restricted to placenta, kidney, testis, uterus, fetal lung, & fetal & adult brain

Pathology

• defects in WNT7A are the cause of
  • limb/pelvis-hypoplasia/aplasia syndrome
  • Fuhrmann syndrome

More general terms

• wnt proto-oncogene protein or int proto-oncogene protein

Database

• UniProt: http://www.uniprot.org/uniprot/O00755.html
• OMIM: https://mirror.omim.org/entry/228930
• OMIM: https://mirror.omim.org/entry/276820
• OMIM: https://mirror.omim.org/entry/601570
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7476