synapsin-1; synapsin I; brain protein 4.1 (SYN1)
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Function
- neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, & is believed to function in regulation of neurotransmitter release
- dephosphorylated form of synapsin-1 'cages' synaptic vesicles
- phosphorylation of synapsin-1 'decages' these vesicles increasing their ability for release
- F-actin may actually form cage
- synapsin may serve to cross-link F-actin
- complex formed with NOS1 & CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level
- substrate of at least four different protein kinases
- phosphorylation probably plays a role in the regulation of synapsin-1 in the nerve terminal
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with CAPON
- forms a ternary complex with NOS1
- isoform Ib interacts with PRNP (putative)
Structure
- homodimer
- belongs to the synapsin family
Compartment
Alternative splicing
Pathology
-defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities ...
More general terms
References
- ↑ Hemmings HC et al Role of protein phosphorylation in neuronal signal transduction FASEB J 3:1583 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2493406
- ↑ Lin JW et al Effects of synapsin I and calcium/calmodulin-dependent protein kinase II on spontaneous neurotransmitter release in the squid giant synapse. PNAS 87:8257 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1978321
- ↑ UniProt http://www.uniprot.org/uniprot/P17600.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SYN1