carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; nitric oxide synthase 1 adaptor protein (NOS1AP, CAPON, KIAA0464)

Function

• adapter protein involved in neuronal nitric-oxide synthesis regulation
• complex formed with NOS1 & synapsins is necessary for specific NO & synapsin functions at a presynaptic level
• mediates indirect interaction between NOS1 & RASD1, facilitating NOS1 activation of RASD1
• competes with DLG4 for interaction with NOS1 by regulating interaction between NOS1 & DLG4 (putative)
• interacts with the PDZ domain of NOS1 via its C-terminal domain
• interacts with RASD1 & SYN1, SYN2 & SYN3 via its PID domain
• forms a ternary complex with NOS1 & RASD1
• forms a ternary complex with NOS1 & SYN1

Structure

contains 1 PID domain

Alternative splicing

named isoforms=3

Polymorphism

• genetic variation in NOS1AP influences the electrocardiographic QT interval

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9722
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9722
• OMIM: https://mirror.omim.org/entry/605551
• OMIM: https://mirror.omim.org/entry/610141
• UniProt: http://www.uniprot.org/uniprot/O75052.html