voltage-dependent Ca+2 channel gamma-2 (neuronal voltage-gated calcium channel gamma-2 subunit, CACNG2)

Function

• stabilizes voltage-dependent Ca+2 channel, L-type Ca+2 channel in an inactivated (closed) state
• interacts with the PDZ domains of DLG4/PSD-95 & DLG1/SAP97
• may interact with GOPC
• phosphorylation of Thr-321 impairs interaction with DLG1 & DLG4

Structure

• belongs to the PMP-22/EMP/MP20 family, CACNG subfamily

Compartment

membrane

Expression

brain

More general terms

• voltage-dependent Ca+2 channel-gamma
• transmembrane 4 protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10369
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10369
• OMIM: https://mirror.omim.org/entry/602911
• UniProt: http://www.uniprot.org/uniprot/Q9Y698.html