L-type Ca+2 channel, long duration or slowly inactivating Ca+2 channel or dihydropyridine receptor (R-type Ca+2 channel)
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Function
- L-type Ca+2 channels (long-lasting) belong to the 'high-voltage activated' (HVA) group
- blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, & by omega-agatoxin-IIIA (omega-Aga-IIIA)
- insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) & omega-agatoxin-IVA (omega-Aga-IVA)
Structure
- subunits
- voltage-dependent Ca+2 channel alpha-1
- voltage-dependent Ca+2 channel alpha-2/delta
- voltage-dependent Ca+2 channel beta
- voltage-dependent Ca+2 channel gamma
More general terms
Components
References
- ↑ Armstrong TINS 12(3) 117 1989
- ↑ Taylor CW, Marshall IC. Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. Trends Biochem Sci. 1992 Oct;17(10):403-7. Review. Erratum in: Trends Biochem Sci 1992 Dec;17(12):493. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1333657
- ↑ Powers PA, Liu S, Hogan K, Gregg RG. Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. J Biol Chem. 1992 Nov 15;267(32):22967-72. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1385409