dihydropyridine

Introduction

A class of calcium channel blockers

Pharmacology

• inhibits L-type calcium channels
• dilation of coronary arteries & arterioles
• increased myocardial oxygen delivery
• decreased systemic vascular resistance
• increased cardiac output
• more selective for vascular smooth muscle than non-dihydropyridine Ca+2-channel blockers
• does not alter contractility or AV nodal conduction

Adverse effects

• headache
• flushing
• dependent peripheral edema
• orthostasis
• tachycardia

More general terms

• pyridine

More specific terms

• amlodipine (Norvasc, Amlocard, Amvaz)
• clevidipine (Cleviprex)
• dihydropyridine Ca+2 channel blocker (CCB)
• felodipine (Plendil)
• isradipine (DynaCirc)
• lercanidipine (Zanidip)
• manidipine
• nicardipine (Cardene, Cardene SR)
• nifedipine (Procardia, Adalat)
• nilvadipine
• nimodipine (Nimotop, Numalize)
• nisoldipine (Sular)
• nitrendipine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=104822