nicardipine (Cardene, Cardene SR)

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Introduction

Tradename: Cardene.

Indications

Contraindications

patients with severe aortic stenosis

Precautions:

  • patients with impaired renal or hepatic function
  • patients with CHF
  • pheochromocytoma
  • may increase the frequency, severity & duration of angina during initiation of therapy

pregnancy category = c

safety in lactation = ?

Dosage

Tabs: 20, 30 mg.

Injection: 2.5 mg/mL (10 mL).

Sustained release: (Cardene SR)

Tabs: 30, 45, 60 mg

Pharmacokinetics

elimination via liver

1/2life = 1.0 hours

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 774
  2. Jump up to: 2.0 2.1 Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998 (Cardene IV)
  4. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. Deprecated Reference

Database