drug interaction(s) of renin-angiotensin-aldosterone inhibitors with trimethoprim-sulfamethoxazole
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Drug interactions
- combination may increase risk of
- hyperkalemia
- it seems as if trimethoprim-sulfamethoxazole is alone among antibiotics in this interaction with renin-angiotensin inhibitors
- increased risk of hyperkalemia & sudden death in elderly taking ACE inhibitors or ARBs[2]
- RR=1.38, absolute risk increase 0.2%[2]
- hyperkalemia
More general terms
References
- ↑ Antoniou T et al. Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: A population-based study. Arch Intern Med 2010 Jun 28; 170:1045. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20585070
- ↑ 2.0 2.1 2.2 Fralick M et al Co-trimoxazole and sudden death in patients receiving inhibitors of renin-angiotensin system: population based study. BMJ 2014;349:g6196 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25359996 <Internet> http://www.bmj.com/content/349/bmj.g6196
Etminan M, Brophy JM Antibiotics and sudden death in adults taking renin- angiotensin system blockers. BMJ 2014;349:g6242 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25360034 <Internet> http://www.bmj.com/content/349/bmj.g6242