drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
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Adverse effects
- increases in serum creatinine after start of a RAAS inhibitor associated with adverse cardiorenal outcomes, even below guideline recommended threshold of a 30% increase for stopping treatment[1]
- concentric hypertrophy of renal arterioles possible leading to renal vascular damage[2]
More general terms
References
- ↑ 1.0 1.1 Schmidt M et al. Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: Cohort study. BMJ 2017 Mar 9; 356:j791 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28279964 Free full text <Internet> http://www.bmj.com/content/356/bmj.j791
- ↑ 2.0 2.1 Zoler ML ACE Inhibitors, ARBs Link With Kidney Damage in Small Study. Medscape. Feb 4, 2022 https://www.medscape.com/viewarticle/967898
Watanabe H, Martini AG, Brown EA et al Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans. JCI Insight. 2021;6(24):e154337 https://insight.jci.org/articles/view/154337