manidipine

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Indications

* potential to be repurposed as COVID-19 therapy[6]

Dosage

5, 10, 20 mg PO QD

Pharmacokinetics

Adverse effects

* peripheral edema allegedly lower than with amlodipine[3]

Drug interactions

  • potentially many

Mechanism of action

More general terms

References

  1. Wikipedia: Mandipine https://en.wikipedia.org/wiki/Manidipine
  2. 2.0 2.1 DRUGBANK Online https://go.drugbank.com/drugs/DB09238
  3. 3.0 3.1 3.2 3.3 3.4 3.5 McKeage K, Scott LJ. Manidipine: a review of its use in the management of hypertension. Drugs. 2004;64(17):1923-40. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15329044
  4. 4.0 4.1 Martinez-Martin FJ, Macias-Batista A, Comi-Diaz C Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study. Clin Drug Investig. 2011;31(3):201-12. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21155616
  5. 5.0 5.1 Saiz-Satjes M, Martinez-Martin FJ, Roca-Cusachs A. Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: differential effect of manidipine versus amlodipine. Future Cardiol. 2017 Mar;13(2):143-151. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27885840
  6. 6.0 6.1 The Scripps Research Institute Extensive study identifies over a dozen existing drugs as potential COVID-19 therapies. MedicalXpress 2021. June 3 https://medicalxpress.com/news/2021-06-extensive-dozen-drugs-potential-covid-.html

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