nifedipine (Procardia, Adalat)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradenames: Procardia, Adalat. Verapamil is the preferred agent in this class.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

Start 10 mg PO TID, max 120 mg/day.

Tabs: 10 & 20 mg.

Hypertensive urgency:

Sustained release: Procardia XL, Adalat CC.

Tabs: 30, 60, 90 mg.

Storage

  • store Procardia in its original container
  • must be protected from light & moisture
  • product labeling for generics does not instruct to dispense in original container

Pharmacokinetics

elimination via liver

1/2life = 2-6 hours

protein binding = 96-98 %

elimination by hemodialysis = -

Adverse effects

* In contrast to clonidine, nifedipine is well tolerated by most patients. It does not cause Na+ retention.

Drug interactions

Laboratory

Mechanism of action

Clinical trials

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 774
  3. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
    non formulary drug request
  6. 6.0 6.1 Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995
  7. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  9. 9.0 9.1 Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
  10. Prescriber's Letter 11(9): 2004 Use of Nifedipine or Tamsulosin for Kidney Stones Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200911&pb=PRL (subscription needed) http://www.prescribersletter.com
  11. 11.0 11.1 Friedman GD et al Antihypertensive Drugs and Lip Cancer in Non-Hispanic Whites Archives of Internal Medicine, August 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22869299 <Internet> http://archinte.jamanetwork.com/article.aspx?articleid=1307567
  12. Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300622&pb=PRL (subscription needed) http://www.prescribersletter.com

Database