nitrate

Classification

• nitroglycerin
• isosorbide dinitrate
• isosorbide mononitrate

Indications

• hypertension
• angina pectoris
  • prophylaxis for angina pectoris
• unstable angina
• acute myocardial infarction
• heart failure

Nitrates may also reduce risk of bleeding peptic ulcers.

Adverse effects

• hypotension in patients with reduced preload
  • usually responsive to
  • volume expansion
  • dose reduction
• headache

• drug adverse effects of antihypertensive agents

Mechanism of action

• metabolites produce relaxation of vascular smooth muscle
• this in turn produces a strong dilation of the veins, reducing preload, wall tension & myocardial oxygen demand

Notes

Nitrate tolerance may occur with continuous exposure.

More general terms

• vasodilator agent

More specific terms

• 2-butyl nitrate
• aristolochic acid
• isosorbide dinitrate (Isordil, Sorbitrate, Isordil Tembids, Dinitrate SR, ISDN)
• isosorbide mononitrate (ISMO, Monoket, Imdur)
• n-butyl nitrate
• nitroglycerin; NTG; TNG (Tridil, NitroBid, Nitrol, Nitrostat, Deponit, Minitran, NitroDur, Nitropaste, Rectiv)

Additional terms

• NO3- (nitrate)

Component of

• nitrate/sodium monofluorophosphate
• miconazole/nitrate/white petrolatum/zinc oxide
• miconazole/nitrate/polymixin b/prednisolone
• miconazole/nitrate
• dimethicone/miconazole/nitrate/zinc oxide
• cortisol/miconazole/nitrate
• chlorpheniramine/methscopolamine/nitrate/phenylephrine
• chlorhexidine/miconazole/nitrate
• nitrate/sodium fluoride
• chlorpheniramine/nitrate/phenylephrine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=944