bleeding time

Reference interval

• Ivy: 2-7 minutes (7-11 minutes is borderline)
• Simplate* (template): 2.5-9.5 minutes
• Mielke (template): < 10 minutes
• Mielke (modified): 2.8 +/- 1.6 minutes
• Duke (ear lobe): 1-3 minutes

* (method of choice)

Increases

(prolonged bleeding time)

• thrombocytopenia (platelets < 60,000-80,000/uL)
• Glanzmann's thrombasthenia
• von Willebrand's disease
• Bernard-Soulier syndrome
• disseminated intravascular coagulation (DIC)
• storage pool disease
• Wiskott-Aldrich syndrome
• Chediak-Higashi syndrome
• oculocutaneous albinims
• hereditary hemorrhagic telangiectasias
• Ehlers-Danlos syndrome
• myeloproliferative disorders
• multiple myeloma & Waldenstrom's macroglobulinemia
• vasculitis
• uremia
• drugs
  • anti-platelet agents
  • non-steroidal anti-inflammatory agents
  • heparin may be associated with increased bleeding time
  • tricyclic antidepressants
  • high-dose beta-lactam antibiotics
  • phenothiazines
  • methylxanthines

Notes

• not reliable
• rarely indicated
• largely replace by platelet aggregation measurement

More general terms

• clinical hematology test

More specific terms

• bleeding time Duke
• bleeding time Ivy

Additional terms

• Bernard-Soulier disease (giant platelet syndrome, benign Mediterranean macrothrombocytopenia)
• disseminated intravascular coagulation (DIC)
• Glanzmann's thrombasthenia
• risk for hemorrhage; hemorrhagic diathesis; bleeding disorder
• storage pool disease
• thrombocytopenia
• uremia
• von-Willebrand's disease (vWD)

Component of

• coagulation screening panel