quinidine [gluconate (Quinaglute, Quinalan) & sulfate (Quinidex, Quinora)]

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Introduction

Group IA antiarrhythmic.

Indications

Contraindications

(cautions)

pregnancy category = c

safety in lactation = ?

Dosage

Quinidine gluconate. Tradenames: Quinaglute, Quinalan.

Quinidine sulfate. Tradenames: Quinidex, Quinora.

  • 200 mg every 6 hours. Max 2.4 g/day Tabs 200, 300 mg.

Sustained release: 300-600 mg PO BID/TID. Tabs 300 mg.

Quinidine polygalacturonate.

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 4-8 hours

protein binding = 70-80 %

elimination by hemodialysis = +

elimination by peritoneal dialysis = +

Monitor

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (ed), Companion Handbook, McGraw Hill, NY, 1994
  3. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150-51
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995
  6. Department of Veterans Affairs, VA National Formulary
  7. 7.0 7.1 deprecated reference

Database