antiarrhythmic agent, Group IA
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Indications
- preexcitation atrial fibrillation
- supraventricular tachycardia
- ventricular arrhythmias
- chemical cardioversion[4]
Mechanism of action
- slows conduction & prolongs repolarization
- like other class I agents, class Ia agents inhibit Na+ influx during phase 0 of the fast sodium channel action potential
- thus class IA agents have local anesthetic & membrane stabilizing properties characteristic of all class I agents
- to a lesser extent, class IA agents also block K+ channels
- thus class Ia agents prolong the action potential duration, repolarization, ventricular refractoriness & the QT interval
More general terms
More specific terms
- disopyramide (Norpace)
- procainamide; novacainamide (Procan Pronestyl-SR)
- quinidine [gluconate (Quinaglute, Quinalan) & sulfate (Quinidex, Quinora)]
References
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150
- ↑ Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 125
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, 16. American College of Physicians, Philadelphia 2009, 2012
- ↑ 4.0 4.1 Deprecated Reference