antiarrhythmic agent, Group I
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Introduction
Class I agents have local anesthetic & membrane stabilizing properties through inhibition of Na+ influx during phase 0 of the fast sodium channel action potential. Class I agents are further classified into Ia, Ib & 1c based upon their effects on conduction & refractoriness.
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References
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150