antiarrhythmic agent, Group IB
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Indications
- treatment of ventricular arrhythmias[2]
Mechanism of action
- class Ib antiarrhythmic agents shorten both the action potential duration & refractoriness at high concentrations
- thus class Ib agents possess local anesthetic & membrane stabilizing properties characteristic of all class I agents
- class Ib agents have less of an effect on inhibition of Na+ influx during phase 0 of the fast sodium channel action potential than do class 1a agents or class 1c agents
- class Ib agents slow conduction in diseased tissue & shorten repolarization[2]
- proarrhythmic effects are less common with class Ib agents than with class Ia agents or class III agents
More general terms
More specific terms
- Lidocaine Parenteral
- mexiletine (Mexitil)
- moricizine (Ethmozine)
- phenytoin; diphenylhydantoin; PTN (Dilantin, Dephenylan, Antilepsin)
- tocainide (Tonocard, Taquidil)
References
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150, 155
- ↑ Jump up to: 2.0 2.1 2.2 Medical Knowledge Self Assessment Program (MKSAP) 15, 16. American College of Physicians, Philadelphia 2009, 2012