antiarrhythmic agent, Group IC
Jump to navigation
Jump to search
Indications
- atrial fibrillation
- atrial flutter
- suproventricular tachycardia
- ventricular arrhythmias
- chemical cardioversion[3]
Contraindications
- class Ic agents should not be used in patients with structural heart disease because of their proarrhythmic potential, including widening of the QRS complex
Mechanism of action
- markedly slows conduction, slightly prolongs repolarization
- class Ic antiarrhythmic agents have little effect on repolarization
- they possess local anesthetic & membrane stabilizing properties characteristic of all class I agents
- class Ic agents have potent effects on inhibition of Na+ influx during phase 0 of the fast sodium channel action potential
More general terms
More specific terms
- dofetilide (Tikosyn)
- encainide (Enkaid)
- flecainide (Tambocor)
- ibutilide (Corvert)
- propafenone (Rythmol, Baxarytmon)
References
- ↑ Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 150, 157
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, 16. American College of Physicians, Philadelphia 2009, 2012
- ↑ Jump up to: 3.0 3.1 Deprecated Reference