ethylenediamine tetra-acetic acid (EDTA, Endrate, calcium disodium versenate, edetic acid, edetate)
Jump to navigation
Jump to search
Introduction
Tradename: Calcium disodium versenate (edetate) *** DISTINGUISH edetate disodium from edetate calcium disodium ***
Withdrawn from US Market 2008 due to safety concerns:
- inappropriate off-label use
- name confusion with edetate calcium disodium)
Indications
- lead poisoning
- may be useful for poisonings due to radioactive & nuclear fission products
- hypercalcemia[6]
Contraindications
Dosage
- 2 g/day or 1.5 g/m2/day divided every 12-24 hours for 5 days
Pharmacokinetics
- well-absorbed after IM or SC administration
- excretion begin 1 hour after IV administration
- peak excretion is seen in 24-48 hours
- most is excreted in the urine within 24 hours
- does not penetrate CSF
- 1/2life is 30-90 minutes
- accumulation is noted with renal dysfunction
elimination via kidney
Adverse effects
- renal/urinary tract
- nephrosis/renal tubular necrosis (may be fatal)
- hematuria
- proteinuria
- tremors
- uncommon (< 1%)
- deaths reported when edetate disodium given, rather than intended edetate calcium disodium[5] due to hypocalcemia ? (edetate disodium is FDA approved as an emergency treatment for certain patients with hypercalcemia)
Mechanism of action
- chelating agents for iron & other heavy metals
- 1 g of calcium EDTA sequesters 620 mg of lead
- EDTA complexes are eliminated in the urine
More general terms
References
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998
- ↑ Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1168
- ↑ Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- ↑ Department of Veterans Affairs, VA National Formulary
- ↑ 5.0 5.1 FDA MedWatch http://www.fda.gov/medwatch/safety/2008/safety08.htm#Edetate
- ↑ 6.0 6.1 Deprecated Reference
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6049
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=159523
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=51808
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=165904
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=115140
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=197149