chondroitin sulfate proteoglycan 5 (neuroglycan C, acidic leucine-rich EGF-like domain-containing brain protein, CSPG5, CALEB, NGC)

Function

• growth & differentiation factor involved in neuritogenesis (putative)
• may induce ERBB3 activation
• binds TNR & probably TNC
• interacts with ERBB3 & GOPC
• N-glycosylated
• O-glycosylated; contains chondroitin sulfate glycans
• part-time proteoglycan
  • expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans
• & in part as a non-proteoglycan form
• relative amount of both forms depends on tissues & tissues maturation
• phosphorylated, in intracellular & extracellular parts

Compartment

• cell membrane
• endoplasmic reticulum membrane, Golgi membrane
• in neurons, localizes to synaptic junctions
• partially enriched in lipid rafts

Alternative splicing

named isoforms=3

Expression

• restricted to brain
• expressed in brain of 3 months, 5 & 10-year-old individuals

More general terms

• proteoglycan core protein

Database

• OMIM: https://mirror.omim.org/entry/606775
• UniProt: http://www.uniprot.org/uniprot/O95196.html