tenascin-R (TN-R, restrictin, janusin, TNR)

Function

• neural extracellular matrix protein
• interactions with different cells & matrix components
  • influences cellular behavior by either evoking a stable adhesion & differentiation, or repulsion & inhibition of neurite growth.
• binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion
  • results in an inhibition of PTK2 phosphorylation & cell detachment
• binding to membrane surface sulfatides results in oligodendrocyte adhesion & differentiation
• interaction with CNTN1 induces a repulsion of neurons & an inhibition of neurite outgrowt
• interacts with SCN2B
  • F3 modules 1-2 & 7-9 mediate interaction with SCN2B
• clustering & regulation of activity of Na+ channels at nodes of Ranvier
• interacts with BCAN & AGC1 (Ca+2-dependent)
  • F3 modules 3-5 mediate interaction with BCAN interacts with SCN2B, PTPRZ1, CSPG3 interacts with CNTN1, TNC, FN1
  • EGF-like domains mediate interaction with CNTN1
• TNR-linked chondroitin sulfate glycosaminoglycans are involved in interaction with FN1 & mediate inhibition of cell adhesion & neurite outgrowth
• addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development & during synapse maintenance
• contains N-linked oligosaccharides, O-linked sialylated structures & O-linked chondroitin sulfate glycosaminoglycans
• contains N-linked oligosaccharides with a sulfated carbohydrate structure

Structure

• forms oligomers
• contains 5 EGF-like domains.
• contains 1 fibrinogen C-terminal domain
• contains 9 fibronectin F3-modules

Compartment

secreted, extracellular matrix

Alternative splicing

named isoforms=2

Expression

• brain specific

More general terms

• tenascin family
• oligomerizing protein

Database

• OMIM: https://mirror.omim.org/entry/601995
• UniProt: http://www.uniprot.org/uniprot/Q92752.html