receptor-type tyrosine-protein phosphatase zeta; R-PTP-zeta; protein-tyrosine phosphatase receptor type Z polypeptide 1; protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2 (PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ)

Function

• may be involved in the regulation of specific developmental processes in the CNS
• the carbonic-anhydrase like domain binds to contactin

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 5 subfamily
• contains 1 alpha-carbonic anhydrase domain
• contains 1 fibronectin F3 module
• contains 2 tyrosine-protein phosphatase domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2; long, short

Expression

• specifically expressed in the central nervous system, where it is localized in the purkinje cell layer of the cerebellum, the dentate gyrus, & the subependymal layer of the anterior horn of the lateral ventricle
• developmentally regulated in the brain

Notes

• formerly termed RPTPase beta
• the human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (chromosome 7) & PTPRZ2 (chromosome 1); however, PTPRZ2 probably does not exist & corresponds to PTPRZ1

More general terms

• tyrosine phosphatase, receptor type
• plasma membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5803
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5803
• OMIM: https://mirror.omim.org/entry/176891
• OMIM: https://mirror.omim.org/entry/604008
• UniProt: http://www.uniprot.org/uniprot/P23471.html