neurocan core protein; chondroitin sulfate proteoglycan 3 (NCAN CSPG3 NEUR)

Function

• may modulate neuronal adhesion & neurite growth during development by binding to neural cell adhesion molecules (NG-CAM & N-CAM)
• chondroitin sulfate proteoglycan; binds to hyaluronic acid

Structure

• belongs to the aggrecan/versican proteoglycan family
• contains 1 C-type lectin domain
• contains 2 EGF-like domains
• contains 1 Ig-like V-type domain (immunoglobulin-like)
• contains 2 link domains
• contains 1 Sushi (CCP/SCR) domain

Expression

brain

More general terms

• proteoglycan core protein

Component of

• neurocan

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1463
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1463
• OMIM: https://mirror.omim.org/entry/600826
• UniProt: http://www.uniprot.org/uniprot/O14594.html