brevican core protein; brain-enriched hyaluronan-binding protein; protein BEHAB (BCAN, BEHAB, CSPG7, UNQ2525/PRO6018)
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Function
- role in terminally differentiating adult nervous system during postnatal development
- may stabilize interactions between hyaluronan & brain proteoglycans
- brevican is integral to the formation of the extracellular matrix's neuroprotective perineuronal nets[2]
- critical regulator of interneuron plasticity
- simultaneously controls cellular & synaptic forms of plasticity in parvalbumin + cells by regulating the localization of potassium channels & AMPA receptors[4]
- Brevican is required for normal cognitive function[4]
- interacts with TNR
- may play a role in myelination
- biomarker of brain aging (negative correlation)*
* higher plasma levels associated with slower brain aging
Structure
- contains mostly chondroitin sulfate
- isoform 2 is predicted to have its GPI-anchor on Asn-649
- belongs to the aggrecan/versican proteoglycan family.
- contains 1 C-type lectin domain
- contains 1 EGF-like domain
- contains 1 Ig-like V-type domain (immunoglobulin-like)
- contains 2 Link domains
- contains 1 Sushi domain (CCP/SCR)
- multiple splice variants, cleavage products, & glycoforms[5]
Compartment
- isoform 1: extracellular matrix
- isoform 2: membrane GPI-anchor
Alternative splicing
named isoforms=2
Expression
- isoform 1:
- highly expressed from birth through 8 years of age
- down-regulated by 20 years of age
- low levels in normal adult cortex
- isoform 2
- expressed at uniformly low levels throughout development
Pathology
- lower MRI white matter hyperintensities associated with lower serum brevican
- brevican is reduced in temporal cortex soluble fractions & frontal cortex synaptosomal fractions in Alzheimer's disease[3]
- CSF levels of brevican positively correlates with age, total tau, p-Tau, neurofilament-L & A-beta40[3]
- component of the glioma tumor microenvironment[5]
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q96GW7.html
- ↑ Jump up to: 2.0 2.1 Chia RSL, Minta K, Wu LY et al Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort. Biomolecules. 2024 Jan 7;14(1):75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38254675 PMCID: PMC10813026 Free PMC article.
Wu LY, Chai YL, Cheah IK, Blood-based biomarkers of cerebral small vessel disease. Ageing Res Rev. 2024 Mar;95:102247. PMID: https://www.ncbi.nlm.nih.gov/pubmed/38417710 Free article. Review. - ↑ Jump up to: 3.0 3.1 3.2 Hohn L, Hubler W, Richter A et al Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer's Disease Patients. Int J Mol Sci. 2023 Mar 14;24(6):5532. doi:http://dx.doi.org/ 10.3390/ijms24065532. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36982604 PMCID: PMC10058969 Free PMC article.
- ↑ Jump up to: 4.0 4.1 4.2 Favuzzi E, Marques-Smith A, Deogracias R et al Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron. 2017 Aug 2;95(3):639-655.e10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28712654 Free article. https://www.cell.com/neuron/fulltext/S0896-6273(17)30552-4
- ↑ Jump up to: 5.0 5.1 5.2 Giamanco KA, Matthews RT. The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility. Adv Exp Med Biol. 2020;1272:117-132. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32845505 Review.
- ↑ Seiler S, Rudolf F, Gomes FR Astrocyte-derived factors regulate CNS myelination. Glia. 2024 Nov;72(11):2038-2060. . PMID: https://www.ncbi.nlm.nih.gov/pubmed/39092473