brevican core protein (brain-enriched hyaluronan-binding protein, protein BEHAB, BCAN, BEHAB, CSPG7, UNQ2525/PRO6018)

Function

• role in terminally differentiating adult nervous system during postnatal development
• may stabilize interactions between hyaluronan & brain proteoglycans
• interacts with TNR

Structure

• contains mostly chondroitin sulfate
• isoform 2 is predicted to have its GPI-anchor on Asn-649
• belongs to the aggrecan/versican proteoglycan family.
• contains 1 C-type lectin domain
• contains 1 EGF-like domain
• contains 1 Ig-like V-type domain (immunoglobulin-like)
• contains 2 Link domains
• contains 1 Sushi domain (CCP/SCR)

Compartment

• isoform 1: extracellular matrix
• isoform 2: membrane GPI-anchor

Alternative splicing

named isoforms=2

Expression

• isoform 1: highly expressed from birth through 8 years of age down-regulated by 20 years of age low levels in normal adult cortex
• isoform 2 expressed at uniformly low levels throughout development

More general terms

• glypiated protein
• hyaluronan-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96GW7.html