Na+ channel protein, 2-beta subunit (SCN2B, UNQ326/PRO386)

Function

• assembly, expression, & modulation of the heterotrimeric voltage-dependent Na+ channel
• covalently linked to the alpha subunit by disulfide bonds
• the beta-2 subunit causes an increase in the plasma membrane surface area & in its folding into microvilli
• may play a crucial role in clustering & regulation of activity of Na+ channels at nodes of Ranvier
• the Na+ channel consists of a pore-forming alpha subunit, beta-1 & beta-2 subunits
• beta-1 is non-covalently associated with alpha while beta-2 is covalently linked by disulfide bonds
• interaction with SCN10A & TNR (putative)

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

membrane; single-pass type 1 membrane protein

Expression

brain specific

More general terms

• voltage-dependent Na+ channel protein beta subunit

Component of

• voltage-dependent Na+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6327
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6327
• OMIM: https://mirror.omim.org/entry/601327
• UniProt: http://www.uniprot.org/uniprot/O60939.html