Na+ channel protein type 10 subunit alpha; Na+ channel protein type X subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.8; peripheral nerve Na+ channel 3; hPN3 (SCN10A, PN3)

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Function

Structure

Compartment

Expression

Pathology

Pharmacology

  • VX-548, an oral, highly selective inhibitor of NaV1.8 (SCN10A)[3]

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q9Y5Y9.html
  2. Rabert DK, Koch BD, Ilnicka M et al A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain. 1998 Nov;78(2):107-114. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9839820
  3. 3.0 3.1 Jones J, Correll DJ, Lechner SM et al Selective Inhibition of NaV1.8 with VX-548 for Acute Pain. N Engl J Med. 2023 Aug 3;389(5):393-405. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37530822 Clinical Trial.

Database