follistatin-related protein 1 (follistatin-like 1, FSTL1, FRP)
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Function
- modulates action of some growth factors in cell proliferation & differentiation (putative)
- binds heparin
- interacts with SCN10A
- role in embryonic development of the heart
- continues to be produced in adulthood
Structure
- contains 2 EF-hand domains
- contains 1 follistatin-like domain
- contains 1 Kazal-like domain
- contains 1 VWFC domain
Compartment
Expression
Pathology
- after myocardial infarction, the epicardium stops producing FSTL1
- FSTL1 patches on the epicardial surface over an infarcted area of myocardium in mice or pigs resulted in regeneration of cardiomyocytes, increased vascularization, diminished scarring, improved contractility, & lengthened lifespan
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q12841.html
- ↑ 2.0 2.1 Wei K et al. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015 Sep 24; 525:479. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26375005
Vunjak-Novakovic G. Cardiac biology: A protein for healing infarcted hearts. Nature 2015 Sep 24; 525:461 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26375007