follistatin; FS; activin-binding protein (FST)
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Function
- activin-binding protein & activin antagonist in vitro
- can bind to heparin sulfate proteoglycans & may function in vivo to present activins to their receptors[1]
- specific inhibitor of the biosynthesis & secretion of pituitary follicle stimulating hormone (FSH)
- follistatin appears to inhibit myostatin[2]
Structure
- monomer (putative)
- contains 3 follistatin-like domains
- contains 3 Kazal-like domains
- contains 1 TB (TGF-beta binding) domain
Compartment
Alternative splicing
named isoforms=3
Expression
- isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid
Pathology
- follistatin deficient mice die within a few hours of birth; defects are more widespread than with activin-deficient mice suggesting that follistatin may modulate the actions of several members of the TGF-beta family
More general terms
References
- ↑ 1.0 1.1 Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature. 1995 Mar 23;374(6520):360-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7885475
- ↑ 2.0 2.1 Benabdallah BF et al Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice. Cell Transplant. 2008;17(3):337-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18522236 UniProt http://www.uniprot.org/uniprot/P19883.html