follistatin; FS; activin-binding protein (FST)

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Function

Structure

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

Pathology

  • follistatin deficient mice die within a few hours of birth; defects are more widespread than with activin-deficient mice suggesting that follistatin may modulate the actions of several members of the TGF-beta family

More general terms

References

  1. 1.0 1.1 Matzuk MM, Lu N, Vogel H, Sellheyer K, Roop DR, Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature. 1995 Mar 23;374(6520):360-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7885475
  2. 2.0 2.1 Benabdallah BF et al Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice. Cell Transplant. 2008;17(3):337-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18522236 UniProt http://www.uniprot.org/uniprot/P19883.html

Database