GPI transamidase component PIG-S; phosphatidylinositol-glycan biosynthesis class S protein (PIGS)

Function

• component of the GPI transamidase complex
• essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates
• glycolipid biosynthesis; GPI-anchor biosynthesis
• forms a complex with PIGK/GPI8, PIGT, PIGU & GAA1

Structure

belongs to the PIGS family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Alternative splicing

named isoforms=2

More general terms

• transmembrane 2 protein
• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)

Additional terms

• phosphatidylinositol [PI] glycan

Component of

• GPI transamidase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=94005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94005
• OMIM: https://mirror.omim.org/entry/610271
• UniProt: http://www.uniprot.org/uniprot/Q96S52.html