glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1 (GPAA1, GAA1)

Function

• essential for GPI-anchoring of precursor proteins
• not essential for GPI synthesis
• acts before or during formation of the carbonyl intermediate
• glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis
• forms a complex with PIGK/GPI8, PIGT, PIGU & PIGS

Compartment

• endoplasmic reticulum membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed in fetal & adult tissues
• expressed at higher levels in fetal tissues than adult tissues

More general terms

• transmembrane 7c protein
• glycoprotein

Additional terms

• glypiated protein

Component of

• GPAA1/PIGK/PIGT/PIGU/PIGS complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8733
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8733
• OMIM: https://mirror.omim.org/entry/603048
• UniProt: http://www.uniprot.org/uniprot/O43292.html