GPI transamidase component PIG-T; phosphatidylinositol-glycan biosynthesis class T protein (PIGT)

Function

• component of the GPI transamidase complex
• essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates
• glycolipid biosynthesis; GPI-anchor biosynthesis
• the disulfide bond between PIGK/GPI8 & PIGT is important for normal enzyme activity
• forms a complex with PIGK/GPI8, PIGS, PIGU & GPAA1/GAA1
• role in maintaining the complex by stabilizing expression of GPAA1 & GPI8 & linking them to PIGS

Structure

belongs to the PIGT family

Compartment

• endoplasmic reticulum membrane
• single-pass type 1 membrane protein

Alternative splicing

named isoforms=4

More general terms

• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
• membrane protein
• glycoprotein

Component of

• GPI transamidase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51604
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51604
• OMIM: https://mirror.omim.org/entry/610272
• UniProt: http://www.uniprot.org/uniprot/Q969N2.html