Na+ channel protein, 3-beta subunit (SCN3B, KIAA1158)

Function

• modulates channel gating kinetics of the voltage-gated Na+ channel
• causes unique persistent Na+ currents
• inactivates the Na+ channel opening more slowly than the subunit beta-1
• its association with neurofascin may target the Na+ channels to the nodes of Ranvier of developing axons & retain these channels at the nodes in mature myelinated axons
• the voltage-sensitive Na+ channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 &/or beta-3 subunits
• beta-1 & beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds.
• beta-1 or beta-3 subunits associate with neurofascin
• associates with SCN10A (putative)

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

membrane; single-pass type 1 membrane protein

More general terms

• voltage-dependent Na+ channel protein beta subunit

Component of

• voltage-dependent Na+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55800
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55800
• OMIM: https://mirror.omim.org/entry/608214
• UniProt: http://www.uniprot.org/uniprot/Q9NY72.html