contactin-1; neural cell surface protein F3; glycoprotein gp135; F11; F3 (CNTN1)
Jump to navigation
Jump to search
Introduction
Contactins mediate cell surface interactions during nervous system development
Function
- formation of paranodal axo-glial junctions in myelinated peripheral nerves
- signaling between axons & myelinating glial cells via association with CNTNAP1
- oligodendrocyte generation
- ligand of NOTCH1, NOTCH1 activation
- interaction with TNR induces repulsion of neurons & inhibition of neurite outgrowth
- interacts with CNTNAP1 in cis form
- binds to carbonic-anhydrase like domain of PTPRZ1
Structure
- monomer
- belongs to the immunoglobulin superfamily, contactin family
- contains 4 fibronectin F3 modules
- contains 6 Ig-like C2-type domain (immunoglobulin-like)
Compartment
- cell membrane, lipid-anchor, GPI-anchor, extracellular side
Alternative splicing
named isoforms=3
Expression
- strongly expressed in brain & in neuroblastoma & retinoblastoma cell lines
- lower levels of expression in lung, pancreas, kidney & skeletal muscle
Pathology
- defects in CNTN1 are the cause of Compton-North congenital myopathy
More general terms
References
- ↑ Br:ummendorf et al Neural cell recognition molecule F11: homology with fibronectin type III and immunoglobulin type C domains. Neuron 1989 Apr;2(4):1351-61 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2627374
- ↑ Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7539963 (HNK-I)
- ↑ UniProt http://www.uniprot.org/uniprot/Q12860.html