contactin-associated protein 1; Caspr1; Caspr; neurexin 4; neurexin IV; p190 (CNTNAP1 CASPR NRXN4)

Function

• seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers
• seems to demarcate paranodal region of axo-glial junction
• in association with contactin may have a role in signaling between axons & myelinating glial cells
• interacts with contactin in cis form

Structure

• belongs to the neurexin family
• contains 2 EGF-like domains
• contains 1 F5/8 type C domain
• contains 1 fibrinogen C-terminal domain
• contains 4 laminin G-like domains

Compartment

membrane

Expression

• predominantly expressed in brain
• weak expression detected in ovary, pancreas, colon, lung, heart, intestine & testis

More general terms

• neurexin
• contactin-associated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8506
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8506
• OMIM: https://mirror.omim.org/entry/602346
• UniProt: http://www.uniprot.org/uniprot/P78357.html