tenascin C; TN; tenascin-C; TN-C; hexabrachion; cytotactin; neuronectin; GMEM; JI; myotendinous antigen; glioma-associated-extracellular matrix antigen; GP 150-225 (TNC, HXB)
Jump to navigation
Jump to search
Function
- extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration
- promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes
- ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 & alpha-V/beta-6
- interacts with CSPG4
Structure
- N-glycosylated (putative)
- homohexamer; disulfide-linked
- a homotrimer may be formed in the triple coiled-coil region & may be stabilized by disulfide rings at both ends; two of such half-hexabrachions may be disulfide linked within the central globule
- belongs to the tenascin family
- contains 15 EGF-like domains
- contains 1 fibrinogen C-terminal domain
- contains 15 fibronectin F3 modules
Compartment
Alternative splicing
named isoforms=6
Expression
induced by TGF-beta
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P24821.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/TNCID42597ch9q33.html
- ↑ Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7539963