receptor tyrosine-protein kinase erbB-3; c-erbB3; tyrosine kinase-type cell surface receptor HER3 (ERBB3, HER3)

Function

• binds & is activated by neuregulins & NTAK
• heterodimer with each of the other ERBB receptors (putative)
• interacts with CSPG5, PA2G4 & MUC1
• ligand-binding increases phosphorylation on Tyr & promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (putative)

Structure

• cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins
• belongs to the protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
• contains 1 protein kinase domain

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

epithelial tissues & brain

Pathology

• overexpressed in a subset of human mammary tumors
• defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2

More general terms

• EGF receptor family protein or erbB proto-oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2065
• OMIM: https://mirror.omim.org/entry/190151
• OMIM: https://mirror.omim.org/entry/607598
• UniProt: http://www.uniprot.org/uniprot/P21860.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2065