neuregulin

Introduction

Of the four family members, neuregulins 1-4, most is known about neuregulin-1.

Function

• ligands for receptor tyrosine kinases ErbB3 & ErbB4, leading to ErbB homodimers or heterodimers, often ErbB2

More general terms

• secreted protein
• growth factor

More specific terms

• neuregulin-1; neu differentiation factor; heregulin; breast cancer cell differentiation factor p45; glial growth factor-2 (NRG1, GGF, HGL, HRG, HRGA, NDF, SMDF, ARIA)
• neuregulin-2, neural-& thymus-derived activator for ERBB kinases; divergent of neuregulin 1; DON-1 (NRG2, NTAK1)
• neuregulin-3 (NRG3)
• neuregulin-4; NRG-4 (NRG4)