neuregulin-1; neu differentiation factor; heregulin; breast cancer cell differentiation factor p45; glial growth factor-2 (NRG1, GGF, HGL, HRG, HRGA, NDF, SMDF, ARIA)
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Function
- direct ligand for ERBB3 & ERBB4 tyrosine kinase receptors
- recruits ERBB1 & ERBB2 coreceptors
- multiple isoforms perform diverse functions
- growth & differentiation of epithelial, glial, neuronal, & skeletal muscle cells
- expression of acetylcholine receptor in synaptic vesicles during formation of neuromuscular junctions
- lobuloalveolar budding & milk production in mammary gland, differentiation of mammary tumor cells
- Schwann cell proliferation
- development of the myocardium
- trabeculation of developing heart
- interacts with LIM domain region of LIMK1
- extensive glycosylation precedes the proteolytic cleavage
Compartment
- cell membrane, secreted, nucleus
- membrane-bound form may not be active
Alternative splicing
Expression
- secreted form(s) expressed in nervous system
- NOT expressed in adult heart, placenta, lung, liver, skeletal muscle, kidney, pancreas
- NOT expression in fetal lung, liver, kidney
- detectable at early embryonic ages
Pathology
- chromosomal translocation t(8;11) involving NRG1 & ODZ4 produced gamma-heregulin
More general terms
References
- ↑ Marchionni MA, Goodearl AD, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M, Danehy F, Misumi D, Sudhalter J, Kobayashi K, et al. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature. 1993 Mar 25;362(6418):312-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8096067
- ↑ UniProt http://www.uniprot.org/uniprot/Q02297.html
- ↑ Protein Spotlight; Tipping the mind - Issue 129 of June 2011 http://web.expasy.org/spotlight/back_issues/sptlt129.shtml