receptor tyrosine-protein kinase erbB-4; p180erbB4; tyrosine kinase-type cell surface receptor HER4 (ERBB4, HER4)

Function

• specifically binds & is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin & NTAK
• interaction with ligand induces cell differentiation
• ligand-binding increases Tyr phosphorylation
• not activated by EGF, TGF-A, & amphiregulin
• isoform JM-A is cleaved but not isoform JM-B is not
• interacts with PDZ domains of DLG2, DLG3, DLG4 & the syntrophin SNTB2
• interacts with CBFA2T3, MUC1 & WWOX

Structure

• homodimer or heterodimer with each of the other ERBB receptors (putative).
• WW-binding motifs mediate interaction with WWOX
• belongs to the protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=3; JM-A, JM-B

Expression

• expressed in brain, heart, kidney, skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis & breast > thymus, lung, salivary gland, & pancreas
• isoform JM-A & isoform JM-B are expressed in cerebellum
• only the isoform JM-B is expressed in the heart

More general terms

• EGF receptor family protein or erbB proto-oncogene protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2066
• OMIM: https://mirror.omim.org/entry/600543
• UniProt: http://www.uniprot.org/uniprot/Q15303.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2066