neuregulin-2, neural-& thymus-derived activator for ERBB kinases; divergent of neuregulin 1; DON-1 (NRG2, NTAK1)

Function

• direct ligand for ERBB3 receptor & ERBB4 receptors
• concomitantly recruits ERBB1 oreceptor & ERBB2 coreceptor, resulting in ligand-stimulated Tyr phosphorylation & activation of the ERBB receptors
• may also promote heterodimerization with the EGF receptor
• proteolytic cleavage close to the plasma membrane on the external face leads to the release of soluble growth factor form (putative)
• extensive glycosylation precedes the proteolytic cleavage
• interacts with ERBB3 & ERBB4

Structure

• the cytoplasmic domain may be involved in regulation of trafficking & proteolytic processing
• regulation of proteolytic processing involves initial intracellular domain dimerization (putative)
• ERBB receptor binding is elicited entirely by the EGF-like domain (putative)
• belongs to the neuregulin family
• contains 1 EGF-like domain
• contains 1 Ig-like C2-type domain

Compartment

• pro-neuregulin-2
  • cell membrane; single-pass type 1 membrane protein
  • does not seem to be active (putative)
• neuregulin-2: secreted (putative)

Alternative splicing

named isoforms=8

Expression

restricted to the cerebellum in the adult

More general terms

• neuregulin
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9542
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9542
• OMIM: https://mirror.omim.org/entry/603818
• UniProt: http://www.uniprot.org/uniprot/O14511.html