beta-2-syntrophin; 59 kD dystrophin-associated protein A1 basic component 2; syntrophin-3; SNT3; syntrophin-like; SNTL (SNTB2 D16S2531E SNT2B2 SNTL)

^[1]^[2]^[3]

Function

adapter protein
binds to & probably organizes the subcellular localization of a variety of membrane proteins
may link various receptors to the actin cytoskeleton & the dystrophin glycoprotein complex
may play a role in regulation of secretory granules via its interaction with PTPRN
phosphorylated; partially dephosphorylated upon insulin stimulation
interacts with other members of the syntrophin family: SNTA1 & SNTB1; & with the Na+ channel proteins SCN4A & SCN5A
interacts with SAST, MAST205, microtubules & microtubule-associated proteins
interacts with the dystrophin protein DMD & related proteins DTNA & UTRN, & with the neuroregulin receptor ERBB4
interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1
dephosphorylation upon insulin stimulation disrupts interaction with PTPRN & results in cleavage of PTPRN

monomer & homodimer (probable)
the 1st PH domain mediates oligomerization (Ca+2 dependent) (putative)
the PDZ domain binds to the last 3 or 4 amino acids of ion channels & receptor proteins; association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (putative)
the SU domain binds calmodulin (Ca+2-dependent) (putative)
belongs to the syntrophin family
contains 1 PDZ domain (DHR domain)
contains 2 PH domains
contains 1 SU domain (syntrophin unique)

one isoform may lack domains required for interaction with dystrophin related proteins
one isoforma may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay