microtubule-associated serine/threonine protein kinase 2 (MAST2, KIAA0807, MAST205)

Function

• appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins
• phosphorylation of DMD or UTRN may modulate their affinities for associated proteins
• functions in a multi-protein complex in spermatid maturation
• regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (putative)
• phosphorylated & ubiquitinated
• N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis
• N-terminal phosphorylation appears to be a prerequisite for ubiquitination (putative)
• interacts with CDHR2

Cofactor: Mg+2 (putative)

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 PDZ domain (DHR domain)
• contains 1 protein kinase domain

Compartment

• cytoplasm, cytoskeleton
• plasma membrane, cytoplasmic side (putative)
• recruited to the sub-membranous area on interaction with CDHR2

Alternative splicing

named isoforms=2

Expression

abundant in the testis

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23139
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23139
• UniProt: http://www.uniprot.org/uniprot/Q6P0Q8.html