receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2 (PTPRN, ICA3, ICA512)

Function

• implicated in neuroendocrine secretory processes
• may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions
• seems to lack intrinsic enzyme activity
• may play a role in the regulation of secretory granules via its interaction with SNTB2
• appears to undergo multiple proteolytic cleavage at consecutive basic residues
• interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1
• dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction & results in its cleavage

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 8 subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

• membrane; single-pass type 1 membrane protein
• neuroendocrine secretory granules

Expression

• expression is restricted to neuroendocrine cells
• found in pancreas, brain & pituitary

Pathology

• autoantigen in insulin-dependent diabetes mellitus (IDDM)

Laboratory

• islet antigen 2 antibody in serum

More general terms

• tyrosine phosphatase, receptor type
• receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5798
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5798
• OMIM: https://mirror.omim.org/entry/601773
• UniProt: http://www.uniprot.org/uniprot/Q16849.html