calpain-1 catalytic [large] subunit (calpain large polypeptide L1, CAPN1)

Function

• Ca+2-regulated non-lysosomal thiol-protease
• catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling & signal transduction
• forms a heterodimer with a small (regulatory) subunit (CAPNS1)
• activated by micromolar concentrations of Ca+2
• inhibited by calpastatin
• broad endopeptidase specificity

Cofactor: binds 3 Ca+2

Structure

• belongs to the peptidase C2 family
• contains 1 calpain catalytic domain
• contains 4 EF-hand domains

Compartment

• cytoplasm (putative)
• cell membrane
• translocates to the plasma membrane upon Ca+2 binding (putative)

Expression

ubiquitous

More general terms

• calpain catalytic or large subunit

Component of

• calpain-1 or calcium-activated neutral protease-mu type

Database

• UniProt: http://www.uniprot.org/uniprot/P07384.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:823
• Kegg: http://www.genome.jp/dbget-bin/www_bget?
• OMIM: https://mirror.omim.org/entry/114220
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=823