dystrophin associated protein complex (DPC)
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Function
- stabilize sarcolemma, protect muscle fibers from long-term contraction induced damage and necrosis
- possible role in cellular communication: acting as transmembrane signaling complex[3]
- dystroglycan ligands include:
Structure
components:
- dystroglycan complex: alpha & beta dystroglycans
- sarcoglycan complex:
- alpha, beta, gamma & delta, zeta sarcoglycans
- sarcospan
- syntrophin
- alpha-dystrobrevin
- nNOS
- SAPK3
- SAST (syntrophin associated serine/threonine kinase)
- skeletal muscle voltage gated sodium channels
- intermediate filament proteins
- aquaporin 4
- in non-muscle tissue, alpha-neurexin & erbB4 are also associated with components of the DPC.
More general terms
References
- ↑ Blake D & Martin-Rendon E Intermediate filaments and the function of the dystrophin- protein complex. Trends Cardiovasc Med 12(5):224-8, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12161077
- ↑ Michele DE & Campbell KP Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function. J Biol Chem 278(18):15457-60, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12556455
- ↑ 3.0 3.1 Muntoni F et al Dystrophin and mutations: one gene, several proteins, multiple phenotypes. Lancet Neurology 2:731-40, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14636778