dystroglycan; dystrophin-associated glycoprotein 1; contains: alpha-dystroglycan (alpha-DG), beta-dystroglycan (beta-DG); DAG1

Function

• part of the dystrophin-associated protein complex (DAPC) which may link cytoskeleton to the extracellular matrix
• mediates acetylcholine receptor aggregation
• alpha-dystroglycan functions as a laminin receptor
• Thr-379 is glycosylated by a trisaccharide with the structure 2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2- (N-acetylamido)-2-deoxyglucosyl-beta-1,4-6-phosphomannose; this trisaccharide constitutes part of the ligand recognized by laminin & agrin
• interacts with SGCD (putative)
• interacts with AGR2 & AGR3

Structure

• glycosylated form as large as 156-200 kD.
• contains 1 peptidase S72 domain

Compartment

• alpha-dystroglycan: secreted, extracellular space
• beta-dystroglycan:
  • cell membrane; single-pass type 1 membrane protein
  • cytoplasm, cytoskeleton

Expression

• expressed in a variety of fetal & adult tissues

Pathology

• target for the entry of Mycobacterium leprae into peripheral nerve Schwann cells
• bound by cellular receptors of several arenaviruses
  • lymphocytic choriomeningitis virus
  • Lassa fever virus
  • Clade C New World arenaviruses

More general terms

• glycoprotein
• membrane protein

More specific terms

• alpha dystroglycan (alpha DG)
• beta dystroglycan (beta DG)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1605
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1605
• OMIM: https://mirror.omim.org/entry/128239
• UniProt: http://www.uniprot.org/uniprot/Q14118.html