delta-sarcoglycan; delta-SG; 35 kD dystrophin-associated glycoprotein; 35DAG (SGCD)

Function

• component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton & the extracellular matrix
• disulfide bonds are present (putative)
• interacts with FLNC & DAG1
• cross-link to form 2 major subcomplexes:
  • one consisting of SGCB, SGCD & SGCG
  • the other consisting of SGCB & SGCD
• association between SGCB & SGCG is particularly strong
• SGCA is loosely associated with the other sarcoglycans (putative)

Structure

• glycosylated
• belongs to the sarcoglycan beta/delta/gamma/zeta family

Compartment

• cell membrane, sarcolemma
• single-pass type 2 membrane protein
• cytoplasm, cytoskeleton

Expression

• most strongly expressed in skeletal & cardiac muscle.
• also detected in smooth muscle
• weak expression in brain & lung

Pathology

• defects in SGCD are the cause of
  • limb-girdle muscular dystrophy type 2F
  • dilated cardiomyopathy type 1L

More general terms

• sarcoglycan
• phosphoprotein

Component of

• sarcoglycan complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6444
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6444
• OMIM: https://mirror.omim.org/entry/601287
• OMIM: https://mirror.omim.org/entry/601411
• OMIM: https://mirror.omim.org/entry/606685
• UniProt: http://www.uniprot.org/uniprot/Q92629.html