alpha-sarcoglycan; alpha-SG; adhalin; 50 kD dystrophin-associated glycoprotein; 50DAG; dystroglycan-2 (SGCA, ADL, DAG2)

Function

• component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton & the extracellular matrix
• interacts with the syntrophin SNTA1
• cross-link to form 2 major subcomplexes:
  • one consisting of SGCB, SGCD & SGCG
  • the other consisting of SGCB & SGCD
• association between SGCB & SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (putative)

Structure

belongs to the sarcoglycan alpha/epsilon family

Compartment

• cell membrane, sarcolemma
• single-pass type1 membrane protein (putative)
• cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2; SGCA-1, SGCA-2

Expression

• most strongly expressed in skeletal muscle
• also expressed in cardiac muscle &, at much lower levels, in lung
• in the fetus, most abundant in cardiac muscle &, at lower levels, in lung
• also detected in liver & kidney
• not expressed in brain

Pathology

• defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D

More general terms

• sarcoglycan

Component of

• sarcoglycan complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6442
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6442
• OMIM: https://mirror.omim.org/entry/600119
• OMIM: https://mirror.omim.org/entry/608099
• UniProt: http://www.uniprot.org/uniprot/Q16586.html