gamma-sarcoglycan; gamma-SG; 35 kD dystrophin-associated glycoprotein; 35DAG (SGCG)

Function

• component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton & the extracellular matrix
• interacts with the syntrophin SNTA1
• cross-link to form 2 major subcomplexes:
  • one consisting of SGCB, SGCD & SGCG
  • the other consisting of SGCB & SGCD
• the association between SGCB & SGCG is particularly strong
• SGCA is loosely associated with the other sarcoglycans (putative)
• interacts with FLNC

Structure

• belongs to the sarcoglycan beta/delta/gamma/zeta family

Compartment

• cell membrane, sarcolemma
• single-pass type 2 membrane protein (putative)
• cytoplasm, cytoskeleton

Expression

expressed in skeletal & heart muscle

Pathology

• defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C

More general terms

• sarcoglycan

Component of

• sarcoglycan complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6445
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6445
• OMIM: https://mirror.omim.org/entry/253700
• OMIM: https://mirror.omim.org/entry/608896
• UniProt: http://www.uniprot.org/uniprot/Q13326.html